Two Strategies for the Development of Mitochondrial-Targeted Small Molecule Radiation Damage Mitigators

PURPOSE: To evaluate the effectiveness of mitigation of acute ionizing radiation damage by mitochondria-targeted small molecules. MATERIALS AND METHODS: We evaluated the nitroxide-linked alkene peptide isostere JP4-039, the nitric oxide synthase inhibitor-linked alkene peptide esostere MCF201-89, an...

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Main Authors: Rwigema, Jean-Claude M., Beck, Barbara, Wang, Wei, Doemling, Alexander, Epperly, Michael W., Shields, Donna, Goff, Julie P., Franicola, Darcy, Dixon, Tracy, Frantz, Marie-Céline, Wipf, Peter, Tyurina, Yulia, Kagan, Valerian E., Wang, Hong, Greenberger, Joel S.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104115/
https://ncbi.nlm.nih.gov/pubmed/21493014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2011.01.059
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