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Aldose reductase deficiency protects sugar-induced lens opacification in rats.
Aldose reductase (AKR1B1), which catalyzes the reduction of glucose to sorbitol and lipid aldehydes to lipid alcohols, has been shown to be involved in secondary diabetic complications including cataractogenesis. Rats have high levels of AKR1B1 in lenses and readily develop diabetic cataracts, where...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3103638/ https://ncbi.nlm.nih.gov/pubmed/21376710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2011.02.028 |
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