Lack of the Long Pentraxin PTX3 Promotes Autoimmune Lung Disease but not Glomerulonephritis in Murine Systemic Lupus Erythematosus

The long pentraxin PTX3 has multiple roles in innate immunity. For example, PTX3 regulates C1q binding to pathogens and dead cells and regulates their uptake by phagocytes. It also inhibits P-selectin-mediated recruitment of leukocytes. Both of these mechanisms are known to be involved in autoimmuni...

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Hauptverfasser: Lech, Maciej, Römmele, Christoph, Kulkarni, Onkar P., Susanti, Heni Eka, Migliorini, Adriana, Garlanda, Cecilia, Mantovani, Alberto, Anders, Hans-Joachim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103530/
https://ncbi.nlm.nih.gov/pubmed/21637713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020118
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