WEE1 inhibition sensitizes osteosarcoma to radiotherapy

BACKGROUND: The use of radiotherapy in osteosarcoma (OS) is controversial due to its radioresistance. OS patients currently treated with radiotherapy generally are inoperable, have painful skeletal metastases, refuse surgery or have undergone an intralesional resection of the primary tumor. After ir...

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Main Authors: PosthumaDeBoer, Jantine, Würdinger, Thomas, Graat, Harm CA, van Beusechem, Victor W, Helder, Marco N, van Royen, Barend J, Kaspers, Gertjan JL
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103478/
https://ncbi.nlm.nih.gov/pubmed/21529352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-156
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