A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro

The 5-nitroimidazole (NI) compound C17, with a side chain carrying a remote phenyl group in the 2-position of the imidazole ring, is at least 14-fold more active against the gut protozoan parasite Giardia lamblia than the 5-NI drug metronidazole (MTR), with a side chain in the 1-position of the imid...

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Hauptverfasser: Dunn, Linda A., Burgess, Anita G., Krauer, Kenia G., Eckmann, Lars, Vanelle, Patrice, Crozet, Maxime D., Gillin, Frances D., Upcroft, Peter, Upcroft, Jacqueline A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103471/
https://ncbi.nlm.nih.gov/pubmed/20456926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijantimicag.2010.03.004
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