Activation of Bone Morphogenetic Protein 4 Signaling Leads to Glomerulosclerosis That Mimics Diabetic Nephropathy

Diabetic nephropathy (DN) is the most common cause of chronic kidney disease. We have previously reported that Smad1 transcriptionally regulates the expression of extracellular matrix (ECM) proteins in DN. However, little is known about the regulatory mechanisms that induce and activate Smad1. Here,...

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Hauptverfasser: Tominaga, Tatsuya, Abe, Hideharu, Ueda, Otoya, Goto, Chisato, Nakahara, Kunihiko, Murakami, Taichi, Matsubara, Takeshi, Mima, Akira, Nagai, Kojiro, Araoka, Toshikazu, Kishi, Seiji, Fukushima, Naoshi, Jishage, Kou-ichi, Doi, Toshio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103383/
https://ncbi.nlm.nih.gov/pubmed/21471216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.179382
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