Scleraxis Modulates Bone Morphogenetic Protein 4 (BMP4)-Smad1 Protein-Smooth Muscle α-Actin (SMA) Signal Transduction in Diabetic Nephropathy

Activation of mesangial cells (MCs), which is characterized by induction of smooth muscle α-actin (SMA) expression, contributes to a key event in various renal diseases; however, the mechanisms controlling MC differentiation are still largely undefined. Activated Smad1 induced SMA in a dose-dependen...

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Detalhes bibliográficos
Main Authors: Abe, Hideharu, Tominaga, Tatsuya, Matsubara, Takeshi, Abe, Naoko, Kishi, Seiji, Nagai, Kojiro, Murakami, Taichi, Araoka, Toshikazu, Doi, Toshio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370223/
https://ncbi.nlm.nih.gov/pubmed/22474292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.275610
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