Lipid Peroxidation Modification of Protein Generates N(ϵ)-(4-Oxononanoyl)lysine as a Pro-inflammatory Ligand

4-Oxo-2(E)-nonenal (ONE), a peroxidation product of ω-6 polyunsaturated fatty acids, covalently reacts with lysine residues to generate a 4-ketoamide-type ONE-lysine adduct, N(ϵ)-(4-oxononanoyl)lysine (ONL). Using an ONL-coupled protein as the immunogen, we raised the monoclonal antibody (mAb) 9K3 d...

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Bibliographic Details
Main Authors: Shibata, Takahiro, Shimozu, Yuuki, Wakita, Chika, Shibata, Noriyuki, Kobayashi, Makio, Machida, Sachiko, Kato, Rina, Itabe, Hiroyuki, Zhu, Xiaochun, Sayre, Lawrence M., Uchida, Koji
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103369/
https://ncbi.nlm.nih.gov/pubmed/21471194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187047
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