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4-Hydroperoxy-2-nonenal Is Not Just an Intermediate but a Reactive Molecule That Covalently Modifies Proteins to Generate Unique Intramolecular Oxidation Products

α,β-Unsaturated aldehydes generated during lipid peroxidation, such as 4-oxoalkenals and 4-hydroxyalkenals, can give rise to protein degeneration in a variety of pathological states. Although the covalent modification of proteins by these end products has been well studied, the reactivity of unstabl...

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Detalhes bibliográficos
Main Authors: Shimozu, Yuuki, Hirano, Keita, Shibata, Takahiro, Shibata, Noriyuki, Uchida, Koji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190737/
https://ncbi.nlm.nih.gov/pubmed/21690609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.255737
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