Serine/Threonine Kinase 17A Is a Novel p53 Target Gene and Modulator of Cisplatin Toxicity and Reactive Oxygen Species in Testicular Cancer Cells

Testicular cancer is highly curable with cisplatin-based therapy, and testicular cancer-derived human embryonal carcinoma (EC) cells undergo a p53-dominant transcriptional response to cisplatin. In this study, we have discovered that a poorly characterized member of the death-associated protein fami...

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Autors principals: Mao, Pingping, Hever, Mary P., Niemaszyk, Lynne M., Haghkerdar, Jessica M., Yanco, Esty G., Desai, Damayanti, Beyrouthy, Maroun J., Kerley-Hamilton, Joanna S., Freemantle, Sarah J., Spinella, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Gene Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103316/
https://ncbi.nlm.nih.gov/pubmed/21489989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.218040
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