Identification of a Novel Bcl-2-interacting Mediator of Cell Death (Bim) E3 Ligase, Tripartite Motif-containing Protein 2 (TRIM2), and Its Role in Rapid Ischemic Tolerance-induced Neuroprotection

We have previously shown that the cell death-promoting protein Bcl-2-interacting mediator of cell death (Bim) is ubiquitinated and degraded following a neuroprotection-conferring episode of brief ischemia (preconditioning). Here, we identify the E3 ligase that ubiquitinates Bim in this model, using...

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Bibliografiske detaljer
Main Authors: Thompson, Simon, Pearson, Andrea N., Ashley, Michelle D., Jessick, Veronica, Murphy, Brona M., Gafken, Philip, Henshall, David C., Morris, Kate T., Simon, Roger P., Meller, Robert
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103311/
https://ncbi.nlm.nih.gov/pubmed/21478148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.197707
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