Cooperative interaction of human HSF1 heat shock transcription factor with promoter DNA.

Eitemau Tebyg

• Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter.
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• Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1
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• Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting.
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• Transcription factor cooperativity with heat shock factor 1
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• Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1.
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