Discovering functional modules by identifying recurrent and mutually exclusive mutational patterns in tumors

BACKGROUND: Assays of multiple tumor samples frequently reveal recurrent genomic aberrations, including point mutations and copy-number alterations, that affect individual genes. Analyses that extend beyond single genes are often restricted to examining pathways, interactions and functional modules...

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Bibliographic Details
Main Authors: Miller, Christopher A, Settle, Stephen H, Sulman, Erik P, Aldape, Kenneth D, Milosavljevic, Aleksandar
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102606/
https://ncbi.nlm.nih.gov/pubmed/21489305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-4-34
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