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Rapid search for specific sites on DNA through conformational switch of nonspecifically bound proteins
We develop a theory for the rapid search of specific sites on DNA, via a mechanism in which a nonspecifically-bound protein can switch between two conformations. In the “inactive” conformation, the bound protein has favorable, nonspecific interactions with the DNA, but cannot be recognized by the ta...
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| 第一著者: | |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3102365/ https://ncbi.nlm.nih.gov/pubmed/21543711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101555108 |
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