Structural insights into cognate versus near-cognate discrimination during decoding

The structural basis of the tRNA selection process is investigated by cryo-electron microscopy of ribosomes programmed with UGA codons and incubated with ternary complex (TC) containing the near-cognate Trp-tRNA(Trp) in the presence of kirromycin. Going through more than 350 000 images and employing...

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Main Authors: Agirrezabala, Xabier, Schreiner, Eduard, Trabuco, Leonardo G, Lei, Jianlin, Ortiz-Meoz, Rodrigo F, Schulten, Klaus, Green, Rachel, Frank, Joachim
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102289/
https://ncbi.nlm.nih.gov/pubmed/21378755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.58
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