RB regulates pancreas development by stabilizing Pdx1

RB is a key substrate of Cdks and an important regulator of the mammalian cell cycle. RB either represses E2Fs that promote cell proliferation or enhances the activity of cell-specific factors that promote differentiation, although the mechanism that facilitates this dual interaction is unclear. Her...

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Autori principali: Kim, Yong-Chul, Kim, So Yoon, Mellado-Gil, Jose Manuel, Yadav, Hariom, Neidermyer, William, Kamaraju, Anil K, Rane, Sushil G
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102287/
https://ncbi.nlm.nih.gov/pubmed/21399612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.57
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