Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis

Ischemic brain injury is a major problem associated with stroke. It has been increasingly recognized that acid-sensing ion channels (ASICs) contribute significantly to ischemic neuronal damage, but the underlying mechanism has remained elusive. Here, we show that extracellular spermine, one of the e...

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Detalhes bibliográficos
Main Authors: Duan, Bo, Wang, Yi-Zhi, Yang, Tao, Chu, Xiang-Ping, Yu, Ye, Huang, Yu, Cao, Hui, Hansen, Jillian, Simon, Roger P., Zhu, Michael X., Xiong, Zhi-Gang, Xu, Tian-Le
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101878/
https://ncbi.nlm.nih.gov/pubmed/21307247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4351-10.2011
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