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Peptide Deformylase Inhibitors as Antibacterial Agents: Identification of VRC3375, a Proline-3-Alkylsuccinyl Hydroxamate Derivative, by Using an Integrated Combinatorial and Medicinal Chemistry Approach

Peptide deformylase (PDF), a metallohydrolase essential for bacterial growth, is an attractive target for use in the discovery of novel antibiotics. Focused chelator-based chemical libraries were constructed and screened for inhibition of enzymatic activity, inhibition of Staphylococcus aureus growt...

Ausführliche Beschreibung

Gespeichert in:
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Chen, D., Hackbarth, C., Ni, Z. J., Wu, C., Wang, W., Jain, R., He, Y., Bracken, K., Weidmann, B., Patel, D. V., Trias, J., White, R. J., Yuan, Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2004
Schlagworte:
Mechanisms of Action: Physiological Effects
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310177/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14693547/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.1.250-261.2004
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