In Vitro Inhibition of the Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Reductase MabA by Isoniazid

The first-line specific antituberculous drug isoniazid inhibits the fatty acid elongation system (FAS) FAS-II involved in the biosynthesis of mycolic acids, which are major lipids of the mycobacterial envelope. The MabA protein that catalyzes the second step of the FAS-II elongation cycle is structu...

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Main Authors: Ducasse-Cabanot, Stéphanie, Cohen-Gonsaud, Martin, Marrakchi, Hedia, Nguyen, Michel, Zerbib, Didier, Bernadou, Jean, Daffé, Mamadou, Labesse, Gilles, Quémard, Annaíik
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC310174/
https://ncbi.nlm.nih.gov/pubmed/14693546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.1.242-249.2004
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