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Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification

<i>Mycobacterium tuberculosis</i>, the pathogen that causes tuberculosis, is responsible for the death of 1.5 million people each year and the number of bacteria resistant to the standard regimen is constantly increasing. This highlights the need to discover molecules that act on new <i>M. tuberculo...

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Main Authors: Léo Faïon, Kamel Djaout, Catalin Pintiala, Catherine Piveteau, Florence Leroux, Alexandre Biela, Stéphanie Slupek, Rudy Antoine, Monika Záhorszká, Francois-Xavier Cantrelle, Xavier Hanoulle, Jana Korduláková, Benoit Deprez, Nicolas Willand, Alain R. Baulard, Marion Flipo
Format: Artigo
Language:Inglês
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
MabA inhibitors
anthranilic acid
FabG1
tuberculosis
mycolic acids
Online Access:https://www.mdpi.com/1424-8247/16/3/335
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