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In Vitro Inhibition of the Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Reductase MabA by Isoniazid
The first-line specific antituberculous drug isoniazid inhibits the fatty acid elongation system (FAS) FAS-II involved in the biosynthesis of mycolic acids, which are major lipids of the mycobacterial envelope. The MabA protein that catalyzes the second step of the FAS-II elongation cycle is structu...
Αποθηκεύτηκε σε:
Κύριοι συγγραφείς: | , , , , , , , , |
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
American Society for Microbiology
2004
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC310174/ https://ncbi.nlm.nih.gov/pubmed/14693546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.1.242-249.2004 |
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