In Vitro Inhibition of the Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Reductase MabA by Isoniazid

The first-line specific antituberculous drug isoniazid inhibits the fatty acid elongation system (FAS) FAS-II involved in the biosynthesis of mycolic acids, which are major lipids of the mycobacterial envelope. The MabA protein that catalyzes the second step of the FAS-II elongation cycle is structu...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ducasse-Cabanot, Stéphanie, Cohen-Gonsaud, Martin, Marrakchi, Hedia, Nguyen, Michel, Zerbib, Didier, Bernadou, Jean, Daffé, Mamadou, Labesse, Gilles, Quémard, Annaíik
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC310174/
https://ncbi.nlm.nih.gov/pubmed/14693546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.1.242-249.2004
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares