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Inactivation of the Indigenous Methyltransferase RlmN in Staphylococcus aureus Increases Linezolid Resistance

The indigenous methyltransferase RlmN modifies A2503 in 23S rRNA. A recently described rlmN mutation in a clinical Staphylococcus aureus isolate decreases susceptibility to linezolid and was thought to increase the extent of A2503 modification. However, we show that the mutation in fact abolishes Rl...

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Bibliografiske detaljer
Main Authors: LaMarre, Jacqueline M., Howden, Benjamin P., Mankin, Alexander S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101465/
https://ncbi.nlm.nih.gov/pubmed/21444696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00183-11
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