Inhibitory Effect of a Triterpenoid Compound, with or without Alpha Interferon, on Hepatitis C Virus Infection

A lack of patient response to alpha interferon (α-IFN) plus ribavirin (RBV) treatment is a major problem in eliminating hepatitis C virus (HCV). We screened chemical libraries for compounds that enhanced cellular responses to α-IFN and identified a triterpenoid, toosendanin (TSN). Here, we studied t...

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Detalhes bibliográficos
Main Authors: Watanabe, Takako, Sakamoto, Naoya, Nakagawa, Mina, Kakinuma, Sei, Itsui, Yasuhiro, Nishimura-Sakurai, Yuki, Ueyama, Mayumi, Funaoka, Yusuke, Kitazume, Akiko, Nitta, Sayuri, Kiyohashi, Kei, Murakawa, Miyako, Azuma, Seishin, Tsuchiya, Kiichiro, Oooka, Shinya, Watanabe, Mamoru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101404/
https://ncbi.nlm.nih.gov/pubmed/21444704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01780-10
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