A Synthetic HIV-1 Subtype C Backbone Generates Comparable PR and RT Resistance Profiles to a Subtype B Backbone in a Recombinant Virus Assay

In order to determine phenotypic protease and reverse transcriptase inhibitor-associated resistance in HIV subtype C virus, we have synthetically constructed an HIV-1 subtype C (HIV-1-C) viral backbone for use in a recombinant virus assay. The in silico designed viral genome was divided into 4 fragm...

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Main Authors: Nauwelaers, David, Van Houtte, Margriet, Winters, Bart, Steegen, Kim, Van Baelen, Kurt, Chi, Ellen, Zhou, Mimi, Steiner, Derek, Bonesteel, Rachelle, Aston, Colin, Stuyver, Lieven J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101197/
https://ncbi.nlm.nih.gov/pubmed/21629677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019643
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