Oligonucleotide-directed self-assembly of proteins: semisynthetic DNA--streptavidin hybrid molecules as connectors for the generation of macroscopic arrays and the construction of supramolecular bioconjugates.

Modified biomolecules were used for the non-covalent assembly of novel bioconjugates. Hybrid molecules were synthesized from short single-stranded DNA and streptavidin by chemical methods using a heterobispecific crosslinker. The covalent attachment of an oligonucleotide moiety to streptavidin provi...

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Main Authors: Niemeyer, C M, Sano, T, Smith, C L, Cantor, C R
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC310113/
https://ncbi.nlm.nih.gov/pubmed/7530841
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