Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction

Emerging evidence suggests that protein acetylation is a broad-ranging regulatory mechanism. Here we utilize acetyl-peptide arrays and metabolomic analyses to identify substrates of mitochondrial deacetylase Sirt3. We identified ornithine transcarbamoylase (OTC) from the urea cycle, and enzymes invo...

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Detalhes bibliográficos
Main Authors: Hallows, William C., Yu, Wei, Smith, Brian C., Devries, Mark K., Ellinger, James J., Someya, Shinichi, Shortreed, Michael R., Prolla, Tomas, Markley, John L., Smith, Lloyd M., Zhao, Shimin, Guan, Kun-Liang, Denu, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101115/
https://ncbi.nlm.nih.gov/pubmed/21255725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.01.002
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