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Cysteine shotgun–mass spectrometry (CS-MS) reveals dynamic sequence of protein structure changes within mutant and stressed cells

Questions of if and when protein structures change within cells pervade biology and include questions of how the cytoskeleton sustains stresses on cells—particularly in mutant versus normal cells. Cysteine shotgun labeling with fluorophores is analyzed here with mass spectrometry of the spectrin–act...

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Autors principals: Krieger, Christine C., An, Xiuli, Tang, Hsin-Yao, Mohandas, Narla, Speicher, David W., Discher, Dennis E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100976/
https://ncbi.nlm.nih.gov/pubmed/21527722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018887108
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