Bispecific digoxigenin-binding antibodies for targeted payload delivery

Bispecific antibodies that bind cell-surface targets as well as digoxigenin (Dig) were generated for targeted payload delivery. Targeting moieties are IgGs that bind the tumor antigens Her2, IGF1R, CD22, or LeY. A Dig-binding single-chain Fv was attached in disulfide-stabilized form to C termini of...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Metz, Silke, Haas, Alexander K., Daub, Karin, Croasdale, Rebecca, Stracke, Jan, Lau, Wilma, Georges, Guy, Josel, Hans-Peter, Dziadek, Sebastian, Hopfner, Karl-Peter, Lammens, Alfred, Scheuer, Werner, Hoffmann, Eike, Mundigl, Olaf, Brinkmann, Ulrich
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2011
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100918/
https://ncbi.nlm.nih.gov/pubmed/21536919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018565108
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы