Bispecific digoxigenin-binding antibodies for targeted payload delivery

Bispecific antibodies that bind cell-surface targets as well as digoxigenin (Dig) were generated for targeted payload delivery. Targeting moieties are IgGs that bind the tumor antigens Her2, IGF1R, CD22, or LeY. A Dig-binding single-chain Fv was attached in disulfide-stabilized form to C termini of...

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保存先:
書誌詳細
主要な著者: Metz, Silke, Haas, Alexander K., Daub, Karin, Croasdale, Rebecca, Stracke, Jan, Lau, Wilma, Georges, Guy, Josel, Hans-Peter, Dziadek, Sebastian, Hopfner, Karl-Peter, Lammens, Alfred, Scheuer, Werner, Hoffmann, Eike, Mundigl, Olaf, Brinkmann, Ulrich
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2011
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100918/
https://ncbi.nlm.nih.gov/pubmed/21536919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018565108
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