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The physiology and pathophysiology of rapamycin resistance: Implications for cancer
Rapamycin is an inhibitor of the mammalian Target of Rapamycin, mTOR, a nutrient-sensing signaling kinase and a key regulator of cell growth and proliferation. While rapamycin and related compounds have anti-tumor activity, a prevalent characteristic of cancer cells is resistance to their anti-proli...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100882/ https://ncbi.nlm.nih.gov/pubmed/21389767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.7.15230 |
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