Rapamycin Response in Tumorigenic and Non-Tumorigenic Hepatic Cell Lines

BACKGROUND: The mTOR inhibitor rapamycin has anti-tumor activity across a variety of human cancers, including hepatocellular carcinoma. However, resistance to its growth inhibitory effects is common. We hypothesized that hepatic cell lines with varying rapamycin responsiveness would show common char...

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Bibliographische Detailangaben
Hauptverfasser: Jimenez, Rosa H., Boylan, Joan M., Lee, Ju-Seog, Francesconi, Mirko, Castellani, Gastone, Sanders, Jennifer A., Gruppuso, Philip A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756589/
https://ncbi.nlm.nih.gov/pubmed/19816606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007373
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