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Crystal structure of the C-terminal domain of human DNA primase large subunit: Implications for the mechanism of the primase—polymerase α switch

DNA polymerases cannot synthesize DNA without a primer, and DNA primase is the only specialized enzyme capable of de novo synthesis of short RNA primers. In eukaryotes, primase functions within a heterotetrameric complex in concert with a tightly bound DNA polymerase α (Pol α). In humans, the Pol α...

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Autori principali: Agarkar, Vinod B, Babayeva, Nigar D, Pavlov, Youri I, Tahirov, Tahir H
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100874/
https://ncbi.nlm.nih.gov/pubmed/21346410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.6.15010
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