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Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation
Hedgehog (Hh) signaling activates full-length Ci/Gli family transcription factors and prevents Ci/Gli proteolytic processing to repressor forms. In the absence of Hh, Ci/Gli processing is initiated by direct Pka phosphorylation. Despite those fundamental similarities between Drosophila and mammalian...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Company of Biologists
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100709/ https://ncbi.nlm.nih.gov/pubmed/21610030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.063479 |
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