Metabolic reprogramming by HIF-1 promotes the survival of bone marrow–derived angiogenic cells in ischemic tissue

A major obstacle to using bone marrow cell-based therapies for ischemic cardiovascular disease is that transplanted cells must survive in an ischemic microenvironment characterized by low oxygen, glucose, and pH. We demonstrate that treatment of bone marrow-derived angiogenic cells (BMDACs) with dim...

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Bibliographic Details
Main Authors: Rey, Sergio, Luo, Weibo, Shimoda, Larissa A., Semenza, Gregg L.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100705/
https://ncbi.nlm.nih.gov/pubmed/21389314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-321190
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