A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression

Fetal hemoglobin (HbF) is regulated as a multigenic trait. By genome-wide association study, we confirmed that HBS1L-MYB intergenic polymorphisms (HMIP) and BCL11A polymorphisms are highly associated with HbF in Chinese β-thalassemia heterozygotes. In this population, the variance in HbF resulting f...

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Autori principali: Farrell, John J., Sherva, Richard M., Chen, Zhi-yi, Luo, Hong-yuan, Chu, Benjamin F., Ha, Shau Yin, Li, Chi Kong, Lee, Anselm C. W., Li, Rever C. H., Li, Chi Keung, Yuen, Hui Leung, So, Jason C. C., Ma, Edmond S. K., Chan, Li Chong, Chan, Vivian, Sebastiani, Paola, Farrer, Lindsay A., Baldwin, Clinton T., Steinberg, Martin H., Chui, David H. K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2011
Soggetti:
Red Cells, Iron, and Erythropoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100700/
https://ncbi.nlm.nih.gov/pubmed/21385855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-317081
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