A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression

Fetal hemoglobin (HbF) is regulated as a multigenic trait. By genome-wide association study, we confirmed that HBS1L-MYB intergenic polymorphisms (HMIP) and BCL11A polymorphisms are highly associated with HbF in Chinese β-thalassemia heterozygotes. In this population, the variance in HbF resulting f...

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Detalhes bibliográficos
Main Authors: Farrell, John J., Sherva, Richard M., Chen, Zhi-yi, Luo, Hong-yuan, Chu, Benjamin F., Ha, Shau Yin, Li, Chi Kong, Lee, Anselm C. W., Li, Rever C. H., Li, Chi Keung, Yuen, Hui Leung, So, Jason C. C., Ma, Edmond S. K., Chan, Li Chong, Chan, Vivian, Sebastiani, Paola, Farrer, Lindsay A., Baldwin, Clinton T., Steinberg, Martin H., Chui, David H. K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100700/
https://ncbi.nlm.nih.gov/pubmed/21385855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-317081
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