In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor

Chronic lymphocytic leukemia (CLL) is characterized by an accumulation of mature CD19(+)CD5(+)CD20(dim) B lymphocytes that typically express the B-cell activation marker CD23. In the present study, we cloned and expressed in T lymphocytes a novel chimeric antigen receptor (CAR) targeting the CD23 an...

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Autors principals: Giordano Attianese, Greta Maria Paola, Marin, Virna, Hoyos, Valentina, Savoldo, Barbara, Pizzitola, Irene, Tettamanti, Sarah, Agostoni, Valentina, Parma, Matteo, Ponzoni, Maurilio, Bertilaccio, Maria T. S., Ghia, Paolo, Biondi, Andrea, Dotti, Gianpietro, Biagi, Ettore
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100686/
https://ncbi.nlm.nih.gov/pubmed/21406718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-311845
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