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Raf-1 Activation Prevents Caspase 9 Processing Downstream of Apoptosome Formation
In many cell types, growth factor removal induces the release of cytochrome-c from mitochondria that leads to activation of caspase-9 in the apoptosome complex. Here, we show that sustained stimulation of the Raf-1/MAPK1,3 pathway prevents caspase-9 activation induced by serum depletion in CCL39/ΔRa...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Hindawi Publishing Corporation
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100593/ https://ncbi.nlm.nih.gov/pubmed/21637382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/834948 |
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