Alloreactivity across HLA barriers is mediated by both naïve and antigen-experienced T cells

T-cell responses to allogeneic targets arise predominantly from the naïve pool. However, in man the risk of graft-versus-host disease (GvHD) is increased if the donor has circulating T cells recognizing multiple persistent DNA viruses, suggesting that memory T cells also contribute to the allorespon...

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Main Authors: Melenhorst, J. Joseph, Scheinberg, Phillip, Williams, Ann, Ambrozak, David R., Keyvanfar, Keyvan, Smith, Melody, McCoy, J. Philip, Hensel, Nancy F., Douek, Daniel C., Barrett, A. John
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100442/
https://ncbi.nlm.nih.gov/pubmed/21215812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2010.12.711
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