Local modulation of striatal glutamate efflux by serotonin 1A receptor stimulation in dyskinetic, hemiparkinsonian rats

Serotonin 1A receptor (5-HT(1A)R) agonists reduce both L-DOPA- and D1 receptor (D1R) agonist-mediated dyskinesia, but their anti-dyskinetic mechanism of action is not fully understood. Given that 5-HT(1A)R stimulation reduces glutamatergic neurotransmission in the dopamine-depleted striatum, 5-HT(1A...

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Autors principals: Dupre, Kristin B., Ostock, Corinne Y., Jaunarajs, Karen L. Eskow, Button, Thomas, Savage, Lisa M., Wolf, William, Bishop, Christopher
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100430/
https://ncbi.nlm.nih.gov/pubmed/21352823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2011.02.012
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