C1 Domain-Targeted Isophthalate Derivatives Induce Cell Elongation and Cell Cycle Arrest in HeLa Cells

Diacylglycerol (DAG)-mediated signaling pathways, such as those mediated by protein kinase C (PKC), are central in regulating cell proliferation and apoptosis. DAG-responsive C1 domains are therefore considered attractive drug targets. Our group has designed a novel class of compounds targeted to th...

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Main Authors: Talman, Virpi, Tuominen, Raimo K., Gennäs, Gustav Boije af, Yli-Kauhaluoma, Jari, Ekokoski, Elina
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100349/
https://ncbi.nlm.nih.gov/pubmed/21629792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020053
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