Direct Evidence for Methyl Group Coordination by Carbon-Oxygen Hydrogen Bonds in the Lysine Methyltransferase SET7/9

SET domain lysine methyltransferases (KMTs) are S-adenosylmethionine (AdoMet)-dependent enzymes that catalyze the site-specific methylation of lysyl residues in histone and non-histone proteins. Based on crystallographic and cofactor binding studies, carbon-oxygen (CH···O) hydrogen bonds have been p...

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Autors principals: Horowitz, Scott, Yesselman, Joseph D., Al-Hashimi, Hashim M., Trievel, Raymond C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099682/
https://ncbi.nlm.nih.gov/pubmed/21454678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.232876
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