Direct Evidence for Methyl Group Coordination by Carbon-Oxygen Hydrogen Bonds in the Lysine Methyltransferase SET7/9

SET domain lysine methyltransferases (KMTs) are S-adenosylmethionine (AdoMet)-dependent enzymes that catalyze the site-specific methylation of lysyl residues in histone and non-histone proteins. Based on crystallographic and cofactor binding studies, carbon-oxygen (CH···O) hydrogen bonds have been p...

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Main Authors: Horowitz, Scott, Yesselman, Joseph D., Al-Hashimi, Hashim M., Trievel, Raymond C.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
主題:
Molecular Biophysics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099682/
https://ncbi.nlm.nih.gov/pubmed/21454678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.232876
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