Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model

Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. We have previously characterized a bigenic PS1×APP transgenic mouse displaying early hipp...

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Bibliographic Details
Main Authors: Jimenez, Sebastian, Torres, Manuel, Vizuete, Marisa, Sanchez-Varo, Raquel, Sanchez-Mejias, Elisabeth, Trujillo-Estrada, Laura, Carmona-Cuenca, Irene, Caballero, Cristina, Ruano, Diego, Gutierrez, Antonia, Vitorica, Javier
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099658/
https://ncbi.nlm.nih.gov/pubmed/21460223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.209718
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