Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice

The ubiquitously expressed kinase GRK2 protects against cellular overstimulation by desensitizing G protein-coupled receptors and regulating intracellular signaling. Recently, we described that hypoxia-ischemia (HI)-induced brain damage was accelerated and increased in GRK2(+/−) neonatal mice. Using...

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Autores principales: Nijboer, Cora H., Heijnen, Cobi J., Willemen, Hanneke L.D.M., Groenendaal, Floris, Dorn, Gerald W., van Bel, Frank, Kavelaars, Annemieke
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099598/
https://ncbi.nlm.nih.gov/pubmed/19932746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2009.11.009
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