Low Endogenous G-Protein-Coupled Receptor Kinase 2 Sensitizes the Immature Brain to Hypoxia–Ischemia-Induced Gray and White Matter Damage

Hypoxic–ischemic brain injury is regulated in part by neurotransmitter and chemokine signaling via G-protein-coupled receptors (GPCRs). GPCR-kinase 2 (GRK2) protects these receptors against overstimulation by inducing desensitization. Neonatal hypoxic–ischemic brain damage is preceded by a reduction...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Nijboer, Cora H. A., Kavelaars, Annemieke, Vroon, Anne, Groenendaal, Floris, van Bel, Frank, Heijnen, Cobi J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670601/
https://ncbi.nlm.nih.gov/pubmed/18367599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4769-07.2008
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