Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies

The anti-CD20 mAb rituximab has substantially improved the clinical outcome of patients with a wide range of B-cell malignancies. However, many patients relapse or fail to respond to rituximab, and thus there is intense investigation into the development of novel anti-CD20 mAbs with improved therape...

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Main Authors: Alduaij, Waleed, Ivanov, Andrei, Honeychurch, Jamie, Cheadle, Eleanor J., Potluri, Sandeep, Lim, Sean H., Shimada, Kazuyuki, Chan, Claude H. T., Tutt, Alison, Beers, Stephen A., Glennie, Martin J., Cragg, Mark S., Illidge, Tim M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2011
Ábhair:
Lymphoid Neoplasia
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099571/
https://ncbi.nlm.nih.gov/pubmed/21378274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-296913
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