Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells

mAbs are becoming increasingly utilized in the treatment of lymphoid disorders. Although Fc-FcγR interactions are thought to account for much of their therapeutic effect, this does not explain why certain mAb specificities are more potent than others. An additional effector mechanism underlying the...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ivanov, Andrei, Beers, Stephen A., Walshe, Claire A., Honeychurch, Jamie, Alduaij, Waleed, Cox, Kerry L., Potter, Kathleen N., Murray, Stephen, Chan, Claude H.T., Klymenko, Tetyana, Erenpreisa, Jekaterina, Glennie, Martin J., Illidge, Tim M., Cragg, Mark S.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2009
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719942/
https://ncbi.nlm.nih.gov/pubmed/19620786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37884
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