Acetaminophen hepatotoxicity and HIF-1α induction in mice occurs without hypoxia

HIF-1α is a nuclear factor important in the transcription of genes controlling angiogenesis including vascular endothelial growth factor (VEGF). Both hypoxia and oxidative stress are known mechanisms for the induction of HIF-1α. Oxidative stress and mitochondrial permeability transition (MPT) are me...

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Autori principali: Chaudhuri, Shubhra, McCullough, Sandra S., Hennings, Leah, Letzig, Lynda, Simpson, Pippa M., Hinson, Jack A., James, Laura P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099476/
https://ncbi.nlm.nih.gov/pubmed/21316383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.02.005
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