Relaxation gating of the acetylcholine-activated inward rectifier K(+) current is mediated by intrinsic voltage sensitivity of the muscarinic receptor

ABSTRACT: Normal heart rate variability is critically dependent upon the G-protein-coupled, acetylcholine (ACh)-activated inward rectifier K(+) current, I(KACh). A unique feature of I(KACh) is the so-called ‘relaxation’ gating property that contributes to increased current at hyperpolarized membrane...

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Autores principales: Moreno-Galindo, Eloy G, Sánchez-Chapula, José A, Sachse, Frank B, Rodríguez-Paredes, J Alberto, Tristani-Firouzi, Martin, Navarro-Polanco, Ricardo A
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2011
Materias:
Cardiovascular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099028/
https://ncbi.nlm.nih.gov/pubmed/21282289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.204115
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