Aspartoacylase-LacZ Knockin Mice: An Engineered Model of Canavan Disease

Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate. The neurological phenotypes of different rodent models of CD vary c...

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Detalhes bibliográficos
Main Authors: Mersmann, Nadine, Tkachev, Dmitri, Jelinek, Ruth, Röth, Philipp Thomas, Möbius, Wiebke, Ruhwedel, Torben, Rühle, Sabine, Weber-Fahr, Wolfgang, Sartorius, Alexander, Klugmann, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098885/
https://ncbi.nlm.nih.gov/pubmed/21625469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020336
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